ꆤ42ꆤ훐맺튽풺튩톧퓓횾2001쓪뗚21뻭뗚1웚ChinHospPharmJ,2001Jan,Vol21,ꆤퟛ쫶ꆤ쏀맺튩컯쿠뮥ퟷ폃볆쯣믺짳닩쾵춳뗄랢햹폫펦폃룅뿶뫺쏷,삵,웑붣,쇵튻량ꆡ(뮪컷튽뿆듳톧튩톧풺,쯄뒨돉뚼610041)[훐춼럖샠뫅]ꆡꆡ[컄쿗뇪쪶싫]Aꆡꆡ[컄헂뇠뫅]100125213(2001)0120042(02)ꆡꆡ튩컯쿠뮥ퟷ폃쫇횸솽훖믲뛠훖튩컯춨맽쿠춬믲늻춬춾ꆡ쾵춳펦뻟놸뗄믹놾쳘뗣ꆡ돽탔쓜짏뗄췪놸췢,튻쳗튩뺶룸폨뫳,퓚쳥쓚닺짺뗄솪뫏킧펦\[1\]ꆣ퓚쪵볊쇙뒲튩톧릤ퟷ컯쿠뮥ퟷ폃짳닩쾵춳펦뻟놸틔쿂믹놾쳘뗣:ꋙ쾵춳쪹폃뷧쏦훐,평폚튩컯늻솼쿠뮥ퟷ폃뛸떼훂룷훖튩풴탔벲늡,쫇랢짺폑뫃ꆢ폐킧;ꋚ쓜릻횸떼죧뫎닉좡뒦샭듫쪩;ꋛ폫폃뮧뗄쪵볹늻뫏샭폃튩뗄훷튪풭틲횮튻ꆣ쏀맺튻쿮폃튩뗷닩뇭쏷,힡풺릤ퟷ쓚죝쿠맘ꆣ늡죋훐,쎿죕폃0ꆫ5훖튩컯,잱퓚튩컯쿠뮥ퟷ폃랢짺싊캪ꆡ쾵춳뗄횪쪶뿢ꆡ튻쳗럻뫏쪵볹탨튪뗄췪짆쾵춳,돽쓜%,쪵볊늻솼랴펦(ADR,adversedrugreaction)랢짺싊캪릻뛔튩컯2튩컯쿠뮥ퟷ폃뗄짳닩췢,뮹펦쓜릻짳닩틔쿂쿮쒿:%;폃6ꆫ10훖튩컯,잱퓚쿠뮥ퟷ폃랢짺싊캪%,쪵ꋙ튩컯뗄맽쏴랴펦;ꋚ훘뢴폃튩;ꋛ튩컯2쪳컯뗄쿠뮥ퟷ폃ꆣ볊ADR랢짺싊캪%;폃11ꆫ15훖튩컯,잱퓚쿠뮥ퟷ폃ꆡ쾵춳뗄탅쾢뇭쫶랽쪽ꆡ쾵춳뗄탅쾢뇭쫶랽쪽펦쪹튩랿랢짺싊캪%,쪵볊ADR랢짺싊캪%ꆣ뻝뗷닩,컒맺쪵볹죋풱쓜릻뛔잱퓚뗄튩컯쿠뮥ퟷ폃톸쯙뺯뻵,춬쪱펦쓜쳡힡풺늡죋욽뻹쎿죕뫏늢쪹폃튩컯5훖,늻뫏샭폃튩랢짺싊듯릩ퟣ릻뗄탅쾢틔쪹웤닉좡쫊틋듫쪩ꆣ퓚뗚튻벶짳닩뷡맻(쾵떽%\[2\]ꆣ퓚쏀맺,폐맘램싉틑맦뚨,튩쪦폐퓰죎볬닩ꆢ풤춳볬닢돶잱퓚쿠뮥ퟷ폃뫳뗄볲튪탅쾢)훐,쾵춳펦뛔튩컯쿠럀늡죋폃튩뗄늻솼쿠뮥ퟷ폃쫂볾\[3\]ꆣ닉좡믽벫듫쪩,볠닢뫍뮥ퟷ폃뗄잱퓚퇏훘탔틔벰랢짺뗄뿉쓜탔ퟷ돶뛈솿ꆣ뛸퓚뗚뇜쏢튩컯쿠뮥ퟷ폃뗄랢짺,틑돉캪룷맺뾪햹쇙뒲뫏샭폃튩릤뛾벶짳닩뷡맻(폃뮧뛔잱퓚튩컯쿠뮥ퟷ폃닺짺뺯뻵뫳,쾵춳ퟷ뗄훘튪쓚죝횮튻ꆣ뷸튻늽쳡릩뗄탅쾢)훐,쾵춳펦쳡릩뒦샭듫쪩랽쏦뗄횸떼ꆣ쯦ퟅ20쫀볍60쓪듺틔뫳볆쯣믺퓚쏀맺튽튩컀짺쇬폲ꆡ펲볾ꆢ죭볾쳘탔ꆡ샭쿫뗄튩컯쿠뮥ퟷ폃짳닩쾵춳뮹펦뗄맣랺펦폃,퓋폃튩컯훎쇆볠닢죭볾쾵춳볠닢뫍횸떼쇙뒲폃뻟놸틔쿂펲볾ꆢ죭볾릦쓜:ꋙ퓊탭폃뮧짨뚨쇙뒲틢틥뗄벶뇰;튩돉캪놣횤늢쳡룟뫏샭폃튩쮮욽뗄폐킧춾뺶횮튻ꆣ튩컯쿠ꋚ횻짳닩늡죋떱잰럾폃뗄튩컯,뛔폚튩샺훐폐볇퓘떫늡죋틑뮥ퟷ폃볆쯣믺짳닩쾵춳ퟷ캪웤훷튪쓚죝횮튻,좡뗃쇋톸쯙뗄춣폃뗄튩컯펦쓜릻벰쪱쟥돽;ꋛ퓊탭폃뮧듲펡돶룅튪탅쾢ꆣ랢햹ꆣ듓70쓪듺훐웚떽90쓪듺돵,퓚쏀맺쇙뒲튩톧쇬폲,1993쓪,SonaElanjian뗈죋쳡돶쇋뛔튩컯쿠뮥ퟷ폃짳닩틑쿈뫳폐HELPꆢMEDIPHORꆢPADISꆢMedicomMicroPlusꆢ죭볾뗄튻냣탔튪쟳,벴:쇏좫쏦ꆢힼ좷ꆢ좨췾ꆢ룼탂욵싊뿬,MedicalLetterꆢS2O2A2PꆢDrugInteractionbyHomstenꆢDTSSꆢ쓜헽좷쪶뇰놻볠닢튩컯뗄뮯톧벰튩샭샠뇰,냼몬늡죋뗄좫쏦RxTriageꆢCross2Check뗈쪮벸훖뻟폐튩컯쿠뮥ퟷ폃짳닩릦쓜폃튩쪷,쓜톸쯙쳡쪾튽짺ꆢ튩쪦잱퓚튩컯쿠뮥ퟷ폃뗄훘튪탔뗄볆쯣믺죭볾쾵춳돉릦퇐훆뫍뾪랢돶살\[\]ꆣ늢쟒,쯦ퟅ웤벰쿠펦뗄뒦훃랽램\[8\]ꆣ릦쓜뗄췪짆ꆢ펦폃쒣쪽뗄돉쫬뫍펦폃킧틦뗄쳡룟,튩컯쿠뮥2ꆡ튩컯쿠뮥ퟷ폃볆쯣믺짳닩쾵춳뗄펦폃킧맻ퟷ폃볆쯣믺짳닩쾵춳퓚쏀맺튽튩쇬폲뗄펦폃죕쟷맣랺ꆣퟷ캪뛔튩쪦뾪햹쇙뒲튩톧릤ퟷ뗄쫖뛎뗄튻훖룄룯,튩컯1996쓪쏀맺튽튩쇬폲뗷닩뇭쏷,쏀맺튽풺튩랿훐펵폐볆쯣믺쿠뮥ퟷ폃볆쯣믺짳닩쾵춳뗄펦폃킧맻쫇뻶뚨웤쪵볊펦폃틢쾵춳뗄햼%,웤훐펦폃볆쯣믺쾵춳볠닢튩컯쿠뮥ퟷ폃뗄틥뗄맘볼ꆣ헫뛔헢튻컊쳢,쏀맺튽튩쇬폲뗄튵죋풱뷸탐쇋폐%\[6\]ꆣ헢킩쾵춳뗄맣랺펦폃,뛔폚쳡룟쏀맺쇙뒲뫏샭듳솿움볛탔퇐뺿릤ퟷꆣ폃튩뗄쮮욽랢믓쇋훘튪뗄ퟷ폃ꆣ놾컄붫뻍쏀맺튩컯쿠뮥ퟷ1975ꆫ1980쓪볤,튻킩쏀맺튩톧튵죋풱춨맽퇐뺿,퇩폃볆쯣믺짳닩쾵춳뗄릦쓜폫탔쓜튪쟳ꆢ쪵볊펦폃뗄킧맻벰뛔횤쇋튩컯쿠뮥ퟷ폃짳닩쾵춳뛔튩컯쿠뮥ퟷ폃랢짺싊볬닢킧웤펦폃킧틦뗄움볛ퟷ튻ퟛ쫶ꆣ맻뗄쪵볊틢틥ꆣFord뗈죋퓸퓋폃쒳튻짳닩쾵춳뛔튻볒튽풺1ꆡ튩컯쿠뮥ퟷ폃볆쯣믺짳닩쾵춳뗄릦쓜폫탔쓜뗄좫늿힡풺늡죋뷸탐벴쪱짳닩,뷡맻랢쿖,퓚77쏻늡죋뗄폃튩컯쿠뮥ퟷ폃볆쯣믺볠닢쾵춳쫇럱쓜폐킧듙뷸튽짺ꆢ튩튩훐,볬닩돶140샽튩컯쿠뮥ퟷ폃,웤훐폐7샽폐훘튪뗄쇙쪦폃튩쮮욽뗄쳡룟틔벰늡죋훎쇆킧맻뗄룄짆,좡뻶폚쾵춳릦뒲틢틥\[9\]ꆣArmstrong뗈죋퓚뷸탐튻쿮샠쯆퇐뺿쪱랢쿖,룹쓜뗄췪짆ꆣ1991쓪뫍1992쓪,Poirier뫍Giudici,틔벰Jankel뻝짳닩쾵춳뗄쳡쪾,쯹볬닩돶뗄튩컯쿠뮥ퟷ폃,뻸듳뛠쫽뿉뫍Martin럖뇰ퟩ횯볒움짳킡ퟩ,뛔쏀맺떱쪱펦폃맣랺뗄틔춨맽뛔늡죋뗄쏜쟐볠닢뛸뇜쏢,%뿉틔춨맽춣튩쿻돽,12훖튩컯쿠뮥ퟷ폃짳닩쾵춳죭볾뫍6훖죭볾뗄릦쓜뷸탐쇋쇭췢폐%춨맽뛔볁솿뗄쫊떱뗷헻벴뿉쿻돽\[10\]ꆣ헢캪튩움볛,퓚듋믹뒡짏,뻍튻룶샭쿫뗄튩컯쿠뮥ퟷ폃짳닩쾵춳펦쪦랢믓웤쇙뒲폃튩뗄횸떼ퟷ폃웰떽쇋뫜듳뗄듙뷸ퟷ폃ꆣ뻟놸뗄릦쓜쓢뚨쇋튻쳗좫쏦뗄뇪ힼ\[\]ꆣ헢쳗뇪ힼ냼삨틔쿂1977쓪,Greenlaw뗈죋퓚쪥쪮ퟖ튽풺뛔PADIS쾵춳뷸벸룶쿮쒿:탐쇋캪웚100d뗄움볛탔퇐뺿ꆣ퇐뺿뷡맻쿔쪾,3룶뛠퓂쓚,ꆡ쾵춳뗄탔쓜뇪ힼꆡ뛔폚튻쳗튩컯쿠뮥ퟷ폃짳닩쾵춳,PADIS릲볬돶1219샽잱퓚뗄쿠뮥ퟷ폃,햼늡샽쫽뗄%;쫗쿈펦듓틔쿂4룶랽쏦뛔웤탔쓜뷸탐움볛:ꋙ쿠뮥ퟷ폃볬닢웤훐뻟폐쇙뒲틢틥뗄폐116샽,햼볬닢쿠뮥ퟷ폃ퟜ쫽뗄쯙뛈;ꋚ랴펳퇏훘탔벶뇰뗄횱맛돌뛈;ꋛ쳡릩탅쾢뗄뿉탅뛈;%,뛸퓚헢116샽쿠뮥ퟷ폃훐,평튩쪦춨맽뛔룸튩쪱볤뗄ꋜ쳡릩탅쾢뗄돤럖탔ꆣ훘탂낲업뛸횱뷓럀횹뗄폐59샽,웤폠퓲평튩쪦럅퓚늡샺훐
훐맺튽풺튩톧퓓횾2001쓪뗚21뻭뗚1웚ChinHospPharmJ,2001Jan,Vol21,ꆤ43ꆤ평튽짺닎뾼,뛸튽풺뛔웤훐82%닉좡쇋믽벫뗄듫쪩ꆣ퇐뺿뮹1979쓪,Kwan뗈죋쳡돶쇋맀쯣튩컯쿠뮥ퟷ폃듸룸튽풺랢쿖,퓚튽풺훐,횧돖PADIS쾵춳뗄튽짺폫늻횧돖헟쿠뇈,횱뷓럑폃뗄랽램ꆣ쯻쏇춨맽듳솿퇐뺿,뗃돶틔쿂뷡싛:1%뗄햼폐룼듳뗄뇈샽,뛸쟒쯦ퟅ퇐뺿뗄뷸탐,헢튻뇈샽퓚늻뛏짏힡풺늡죋믡돶쿖폐쇙뒲틢틥뗄튩컯쿠뮥ퟷ폃,웤훐쎿캻늡죋짽,훁퇐뺿뷡쫸,좫풺틑폐81%뗄늡죋뗄훷훎튽짺횧돖룃쾵뗄힡풺쪱볤붫퇓뎤3d(1d폃폚닩쏷쿠뮥ퟷ폃,2d폃폚뷢뻶춳\[11\]ꆣ쿠뮥ퟷ폃듸살뗄컊쳢)ꆣ틲듋,쳡돶뛔쿠뮥ퟷ폃횱뷓럑폃맀1979쓪,Kwan뗈죋퓚튻쿮뛔튩컯쿠뮥ퟷ폃뗄랢짺싊ꆢ쯣릫쪽죧쿂:횱뷓럑폃=쎿쓪뒦랽솿ꇁꇁ쳬쫽ꇁ욽뻹쎿쿠뮥ퟷ폃쇙뒲틢틥벰웤펰쿬뗄믘맋탔퇐뺿훐,춨맽볆쯣믺쾵죕늡죋힡풺럑폃\[15\]ꆣHaumschild뗈죋퓚튽춳쫕벯쇋5200쏻늡죋뗄쿠뮥ퟷ폃쇏ꆣ퇐뺿뷡맻뇭쏷,볬풺훐펦폃쇋짏쫶랽램,뷡맻랢쿖,춨맽복짙튩컯쿠뮥ퟷ폃쫽닢돶뗄튩컯쿠뮥ퟷ폃훐,폐10%뻟폐쇙뒲틢틥늢뛔튽풺훐솿,쎿쓪뿉틔뷚쪡308259쏀풪뗄횱뷓럑폃\[13\]ꆣ1%뗄늡죋닺짺쇋늻솼펰쿬ꆣ뛸헢훖펰쿬떼훂뗄뫳맻쫇쎿쓪ퟛ짏쯹쫶,쏀맺튩컯쿠뮥ퟷ폃볆쯣믺짳닩쾵춳틑뻟폐뷏퓶볓쇋29250쏀풪뗄훎쇆럑폃\[12\]ꆣ췪짆뗄릦쓜뫍뷏돉쫬뗄펦폃쒣쪽,늢뻟폐쏷쿔뗄짧믡킧틦폫1985쓪,Haumschild뗈죋뛔Minipharm쾵춳뷸탐뗄캪웚뺭볃킧틦ꆣ퓚컒맺,쒿잰룷튽풺볆쯣믺펦폃죕쟷폚웕벰,쏦튻쓪뗄퇐뺿훐,볬돶잱퓚튩컯쿠뮥ퟷ폃1004샽ꆣ퓚뛔튩컯뛔?듽뷢뻶뗄튩컯쿠뮥ퟷ폃컊쳢뫍튽쇆럑폃짏헇컊쳢,컒쏇쿠뮥ퟷ폃뗄뒦샭훐,튽짺룄뇤튩컯볁솿뗄늡샽햼44%,뛸뛔펦뷨본쏀맺돉쫬뗄릤ퟷ랽램뫍럡뢻뗄쪵볹뺭퇩,뷡뫏컒맺뗄늡죋볠닢뗄늡샽햼75%ꆣ쇭췢,쾵춳뗄펦폃듙쪹쇋튽짺뫍튩쪵볊쟩뿶,톸쯙뾪랢늢췆맣럻뫏컒맺맺쟩뗄튩컯쿠뮥ퟷ폃볆쪦뛔튩컯쿠뮥ퟷ폃뗄ퟔ뻵볠닢,ꋱ벶쿠뮥ퟷ폃퓚퇐뺿뗄3룶쯣믺짳닩쾵춳ꆣ퓂훐훰퓂쿂붵,뗚튻룶퓂돶쿖27샽,뗚뛾룶퓂돶쿖12샽,뗚닎뾼컄쿗:죽룶퓂뷶돶쿖4샽\[13\]ꆣ\[1\]ꆡ돂탂잫,뷰폐풥훷뇠.탂뇠튩컯톧\[M\]뗚.14냦.놱뺩:죋쏱컀튩컯쿠뮥ퟷ폃볆쯣믺짳닩쾵춳퓚쏀맺튽튩쇬폲뗄펦폃짺돶냦짧,쪵볹틔벰튽튩튵죋풱뗄퇐뺿뷡맻뇭쏷\[2\]ꆡ훜풪퇾훷뇠.튩컯쇷탐늡톧\[M\]놱.뺩:훐맺튽튩뿆벼돶냦짧,,룃쾵춳뗄펦폃,늻뷶뇜쏢쇋듳솿뗄튩컯쿠뮥ퟷ폃쯹훂뗄튩몦쫂볾,쳡룟쇋쇙뒲1996:5뫏샭폃튩뗄쮮욽,뛸쟒듳듳쳡룟쇋쇙뒲튩쪦퓚쇙뒲쪵볹릤ퟷ\[3\]ꆡ\[J\].Co2ntempPharmPract,1981,4(2):211훐뗄뗘캻,퓶잿쇋튽짺폫튩쪦볤뗄붻쇷폫뫏ퟷꆣ\[4\]ꆡꆡ튩컯쿠뮥ퟷ폃볆쯣믺짳닩쾵춳뗄펦폃킧틦macy197521981\[J\].AmJHopsPharm,1982,39(1):53볆쯣믺퓚튽튩쇬폲펦폃뗄뺭볃톧킧틦튻횱쫇쏀맺튽튩\[5\]ꆡJonkelCA,튵죋풱맘힢뗄훘뗣,폈웤퓚뷼30쓪,튽쇆럑폃죕붥퓶뎤뛸actionscreeningprograms\[J\].AmJHopsPharm,1992,49(7):헾뢮춶죫뺭럑폐쿞,튩컯쿠뮥ퟷ폃볆쯣믺짳닩쾵춳뗄펦폃쓜1430럱믱뗃뷏룟뗄돉놾2킧틦,췹췹쫇튽쇆늿쏅뻶뚨쫇럱쪹폃헢\[6\]ꆡReederCE,MikeDickson,KozmaCM,튻쾵춳뗄맘볼ꆣ쏀맺튩톧튵퇐뺿죋풱헫뛔헢튻컊쳢뷸탐veyofpharmacypracticeinacutecaresettings21996\[J\].AmJ쇋쾵쇐퇐뺿ꆣHealth2SystPharm,1997,54(3):653\[7\]ꆡPoirierTI,쓪7퓂ꆫ1979쓪7퓂,Greenlaw뗈죋볌뛔PADISputersoftware:comparativestudy\[J\].HopsPharm,1991,26(1):쾵춳뗄움볛탔퇐뺿횮뫳,뛔쾵춳퓋탐뗄뺭볃톧킧틦뷸탐쇋캪30웚튻쓪뗄퇐뺿ꆣ퇐뺿죋풱쫗쿈뛔쾵춳퓋탐뗄쓪뛈ퟜ럑폃뷸\[8\]ꆡSonaElanjian,MaryLG,탐쇋움맀,뺭맽훰튻럖컶,뗃돶쾵춳퓋탐뗄쓪뛈ퟜ럑폃캪departmentstoidentifydruginteractions\[J\].AmJHopsPharm,쏀풪1993,50(12):2546(웤훐킽뷰햼63%,볆쯣믺럑폃햼17%,쫽뻝뿢럑폃캪16%,횽헅뗈럑폃햼4%)ꆣ쯦뫳,퇐뺿죋풱듓틔쿂\[9\]ꆡFordDR,RiversNP,룶랽쏦뛔쾵춳퓋탐뗄돉놾2킧틦뷸탐쇋럖컶:ꋙ쎿늡샽죕럑forpotentiallysignificantadversedruginteractions\[J\].JAm폃PharmAssoc,1977,NS17:354;ꋚ뗷볁쎿훖튩욷럑폃;ꋛ쎿샽볬돶폫볠닢잱퓚뗄튩컯쿠\[10\]ArmstrongWA,DrieverrCW,뮥ퟷ폃럑폃;ꋜ쎿샽놻럀횹뗄뻟폐쇙뒲틢틥뗄쿠뮥ퟷ폃럑teractionsinageriatricpopulation\[J\].AmJHopsPharm,1980,37폃ꆣ춳볆뷡맻뇭쏷,튻쓪횮훐,쪥쪮ퟖ튽풺릲폐131355룶늡(2):385샽죕,뗷엤럖랢쇋429훖튩욷;뛸퓋폃PADIS쾵춳,릲볬돶\[11\]샽잱퓚뗄튩컯쿠뮥ퟷ폃,웤훐314샽쿠뮥ퟷ폃(%)screeningsystem\[J\].AmJHopsPharm,1981,38(4):517폐쇙뒲틢틥늢놻폐킧럀횹ꆣ믹폚헢킩쫽뻝,G\[12\]LwanPC,WahbaWW,:retro2reenlaw뗈죋뛔쾵춳퓋탐뗄돉놾킧틦럖컶뗃돶틔쿂뷡맻:쎿늡샽죕쾵춳퓋탐spectivestudyofitsepidemiology,Clinicalsignificanceandinflu2럑폃캪enceuponhospitalization\[J\].CanJHopsPharm,1979,32(1):쏀풪,뗷훆쎿훖튩욷럑폃캪쏀풪,볬돶폫볠\[13\]HaumschildMJ,WardES,BishopJM,닢쎿샽잱퓚튩컯쿠뮥ퟷ폃뗄럑폃캪쏀풪;뛸쇭튻랽쏦,putersystemformonitoringandreportingdruginteractions\[J\].쎿샽놻럀횹뗄폐쇙뒲틢틥뗄쿠뮥ퟷ폃럑폃캪쏀풪\[14\]ꆣAmJHospPharm,1987,44(2):345뛸듋잰,Dick뗈뛔3훖쫖릤샍뚯뗄랽쪽(닩퓄늡샺뇭ꆢ폫튽짺\[14\]튻웰닩랿ꆢ붨솢늡죋폃튩볇슼)볬닢폃튩컊쳢뗄킧틦럖컶뇭system\[J\].AmJHopsPharm,1981,38(4):521쏷\[15\]DickML,WinshipHW,,닩퓄늡샺뇭랽쪽볬돶튻샽잱퓚뗄튩컯쿠뮥ퟷ폃탨튪쏀풪,캪쾵춳볬닢뗄21놶;뛸춨맽닩뾴늡죋볇슼볬돶ofapharmacistusingthreemethodsforidentifyingpossibledrug튻샽탨튪relatedproblems\[J\].DrguIntellClinPharm,1975,9(2):쏀풪,캪쾵춳볬닢뗄6놶\[15\]ꆣ쾵춳퓚튽풺뗄퓋탐뻟폐뫜룟뗄짧믡킧틦뫍뺭볃킧틦ꆣ[쫕룥죕웚]2000203221
