• Overview of research in Biophysics
Institute @NCU. 中央大學生物物理所
• From DNA to collective behavior of
organisms
Soft Condensed
Matter
Biophysics
Institute of BioPhysics at NCU
中央大學生物物理所
Physics Dept. Center for Complex Systems複雜系統中心
Brain Research Center,UST
聯合大學腦科學中心
Life Science
生命科學系
Institute of
Phys., Academia
Sinica
中研院物理所
Inst. Systems Biology & Bioinformatics
系統生物所
Why BioPhysics ?
• Material Nature of Bio-substances affect
Biological properties. (Evolution made use
of the physical properties of bio-materials)
• Physical principles & Laws holds from
microscopic level macroscopic level
• Traditional Biology is descriptive, non-
quantitative
Why BioPhysics ?
• Physics is universal.
• Rise of molecular biology: DNA, RNA, protein
are universal in all living matters
• Universality in Central Dogma:
DNARNAproteinBiological functions…
• New, interesting, exciting & useful.
• Lots of unsolved important problems.
• Techniques & Methodology in physics can probe
the fundamental principles in bio-systems of a
wide spectrum of scales in a quantitative way.
國立中央大學 生物物理研究所
• Officially established in 2004
• 教授: 6 副教授: 1 助理教授 3
• 合聘教授: 2 合聘助理教授: 1
• 現有從事生物物理領域在學研究生
碩士班：23 博士班：8
• 博士後: 3
• 以物理之技術或方法去探討生物系統中存在之
基本原理，從而對生物過程提供深入及定量之
了解。
• 「5年500億」頂尖中心經費建立生物物理共
用核心設施
• 歡迎物理與非物理背景同學加入.中大及中研
院提供獎學金
BioPhysics Institute @NCU
• Officially established in 2004
• Professors: 6 Assoc. Prof.: 1 Assist. Prof. 3
• Adj. Prof.: 2 Adj. .: 1
• Graduate students working on areas in biophysics
.：23 Ph. D.：8
• Postdocs: 5
• aims at achieving some quantitative description of
biological processes and search for the fundamental
principles buried in these highly complex biological
phenomena
• 「5 years 500B」grant to support research &
building of core facility labs.
• Cross-disciplinary: researchers/students from
physics & non-physics background
師 資 職 稱 研究專長 Email Address
李 弘 謙
Hoong-Chien Lee
教 授
Professor
McGill University
計算生物/生物物理/生物訊息 (理論) hclee@
伊 林
Lin I
教 授
Professor
Rutgers University
複雜系統/生物物理 (實驗) lini@
陳 方 玉
Fang-Yu Chen
教 授
Professor
Rice University
生物物理/生物膜 (實驗) fychen@
黎 璧 賢
Pik-Yin Lai
教 授
Professor
University of Pittsburgh 生物物理/軟凝態物理/神經元網路/生物材料 (理
論/實驗)
pylai@
王 敏 生
Min-Sheng Wang
教 授
Professor
University of Pittsburgh
腦科學 (理論) mswang@
高 仲 明
Chung-Ming Ko
教 授
Professor
University of Arizona
演化的模擬 (理論) cmko@
陳 培 亮
Peilong Chen
副 教 授
Associate Professor
Caltech
生物圖案形成/軟物質/生物力學 (理論/實驗) peilong@
陳 宣 毅
Hsuan-Yi Chen
助理教授
Assistant Professor
University of Pittsburgh
軟凝態物理/生物物理 (理論) hschen@
薛 雅 薇
Ya-Wei Hsueh
助理教授
Assistant Professor
University of Toronto
生物膜物理/核磁共振 (實驗) yhsueh@
李 紀 倫
Chi-lun Lee
助理教授
Assistant Professor
SUNY Stony Brook
軟凝態物理/生物物理 (理論) chilun@
陳 志 強
Chi-Keung Chan
合聘教授
Joint Appointment
Professor
University of Pittsburgh
軟物質/生物物理/神經元網路 (實驗) phckchan@
梁 鈞 泰
Kwan-tai Leung
合聘教授
Joint Appointment
Professor
UC Santa Barbara
統計物理與軟物質/生物集體行為(理論) leungkt@
林 耿 慧
Keng-Hui Lin
合聘助理教授
Joint Appointment
Assistant Professor
University of
Pennsylvania 軟物質/生物材料 (實驗) khlin@
Wide Spectrum
• Length Scales:
nm mm mm cm m km
DNA,RNA,protein, intracellular, virus, bacteria, Intercellular, collective motion, insects, animanls/plants, migration
• Time Scales:
fs ps ms ms s
e transfer,H-bonding,water DNA,RNA,protein rearrangement , protein folding DNA transcription
hr day year Byr
cell division Earth organisms , animal migration evolution
• Knowledge: Interdisciplinary 跨越各學科領域
MathematicsPhysicsChemistryBiologyMedical
• Biophysicist is a TRUE Scientist !
• 需要物理與非物理背景人材加入!
BioPhysics Theory Groups at NCU
• 陳培亮 Peilong Chen: bio-hydrodynamics, mechanics of
propulsion in living organisms, pattern formation in biology
• 陳宣毅 Hsuen-Yi Chen: complex fluids, cell adhesion,
collective motion in flocks
• 黎璧賢 Pik-Yin Lai: DNA physics, biomolecular chain
models, neurons, biological networks
• 李紀倫 Chi-Lun Lee: protein folding, charged biomolecules
• 梁鈞泰 Kwan-tai Leung: self-propelling motion in
organisms, flocking, non-equilibrium bio-processes
• 高仲明 Chung-ming Ko: Evolution models, astrobiology
• 王敏生 Min-Sheng Wang: Neural Networks, brain wave &
MEG analysis
• 李弘謙 Hoong-Chien Lee: Bioinformatics, protein physics,
genome/DNA sequence analysis
Soft
matters
Biophysics
BioPhysics Experimental Labs at NCU
• Complex System Lab.伊林 Lin I: micro-motion of bio- and soft materials
in confined spots, dynamics of neuronal system, laser pulse-soft matter
interaction
• Biophysics Lab.陳方玉 Fang Yu Chen: Biomembrane, Membrane-active
Peptides, Effect of peptide-forming pore on neuron function
• Soft-condensed Matter Lab.陳培亮 Peilong Chen: bio-hydrodynamics,
mechanics of propulsion in living organisms
• Bio-Soft Matters Lab.黎璧賢 Pik-Yin Lai, 陳志強 . Chan & 林耿慧 :
interactions in cells, neuronal networks, DNA mechanics & hydrodynamics,
biomaterials
• Bio-Soft Core Facilities Lab. : BioAFM, Confocal microscopy, Wet
Labs, Bio samples, fast imaging systems, fluorescence microscopy…
• Bio-membrane Lab.薛雅薇 Ya-Wei Hsueh: lipid rafts in cell membranes, NMR
spectroscopy, AFM measurement
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